ALFAREKIN ®

ALFAREKIN ®
Product Code: 92
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ALFAREKIN ®  1000000 IU vial

Description for ALFAREKIN

Pharmacological properties: Alfarekin similar natural leukocyte interferon, has three main types of biological activity: immunomodulatory, antiviral and anticancer.
The mechanism of action is based on Alfarekina binding of interferon to specific receptors of cells of the body, resulting in a cascade of intracellular reactions triggered and the synthesis of enzymes which depress viral replication, increased phagocytic activity of macrophages and lymphocytes specific cytotoxicity relative to the target cells, inhibiting proliferation of metastatic cells.

INDICATIONS: in the complex treatment of adults and children with:
viral hepatitis B and C;
acute viral, bacterial and mixed infections (including newborns);
acute and chronic septic diseases of viral and bacterial origin;
herpetic infections of different localization (shingles, multiple cutaneous herpes, genital herpes infection, herpetic keratoconjunctivitis and keratouveit, etc.);
chronic urogenital chlamydiosis;
lesions of the nervous system with mono-and poliradikulyarnym pain;
papillomatosis of larynx;
multiple sclerosis;
malignancies: melanoma of the skin and eyes, kidney cancer, bladder, ovaries, breast cancer, Kaposi's sarcoma, multiple myeloma;
hematological malignancies: chronic myelogenous leukemia, hairy leukemia, Hodgkin's malignant lymphoma.

APPLICATION: pp Alfarekina injected i / m, n / a, a / c, endolimfalno, intraperitoneally, intravesically, rectally, parabulbarno, intranasally. The dissolution of the contents of the vial in 1 ml of the solvent water is used for injection by dissolving the contents of the vial at a higher level using physiological pp.
Acute hepatitis B:
administered to 1 million IU (in severe cases - by 2 million IU) / m 2 twice daily for 10 days. The course of treatment can be extended up to 2-3 weeks depending on the patient's general condition, or extended by 1 million IU 2 times a week for several weeks.
Chronic hepatitis B:
injected i / m of 3-4 million IU 3 times a week for 2 months.
Chronic viral hepatitis C:
injected i / m at 3 million IU 3 times a week for 6 months as monotherapy or in combination with drugs-nucleoside analogues.
SARS in children (including newborns):
administered intranasally with 2-3 drops in each nostril 3-6 times a day for 3-5 days, the dosage for newborns - 20-50 thousand IU / ml, for children of other age groups - 100 thousand IU / ml.
Permissible to introduce into the nasal passages (in turn) turundas cotton, soaked Alfarekinom for 10-15 minutes.
ARI (including influenza) in adults:
injected i / m 1-3 million IU, starting with 1-2 days of disease within 3 days;
intranasally administered at 4-6 drops Valium Alfarekina (100 thousand IU / ml) in each nostril 6-8 times a day (before applying to be entered by the dose Alfarekina stir in the syringe (use a syringe without a needle) to body temperature, the rest rr stored in the refrigerator, protected from bacterial contamination).
Acute and recurrent viral pneumonia and viral-bacterial etiology:
/ m at 1 million IU for 5-7 days in the combined treatment, including antibacterial, detoxication, anti-inflammatory therapy.
Acute diarrheal syndrome in infants:
rectally in the form of daily mikroklizmochek containing 100 thousand IU Alfarekina, within 3-7 days.
Acute intestinal infections in young children with hypocoagulation:
administered rectally in a dose of 10 thousand IU / kg body weight 3 times every 48 hours
Pyo-septic diseases, peritonitis, abdominal abscesses are multiple:
I / O, 2-4 MIU 1 time per day, total dose: 12-16 million U per treatment.
Herpetic infection:
zoster: daily / m - 1 and 2 MIU MIU in 5 ml of physiological Valium n / a in a few points around the zone of the rash. Duration of treatment - 5-7 days.
cutaneous herpes: 2 million IU / m or s / c (around lesion) on a daily basis, treatment can be combined with local application (applications) on herpetic papules.
Genital herpes infection: 2 million IU / m daily in combination with local application of the drug in the form of applications for the area of ​​rash.
herpetic keratoconjunctivitis: 1 million IU Alfarekina dissolved in 5 ml of physiological Valium is injected conjunctiva with 2-3 drops every 2 hours for 7-10 days with a decrease in symptoms of the disease agent can be administered every 4 hours
Chronic urogenital chlamydia:
Alfarekin used in the adjuvant therapy - to 1 million IU / m 1 time per day in the evening, on a course of treatment - 10 injections.
Damage to the nervous system with mono-and poliradikulyarnym pain syndrome:
1 million IU / m for 5-10 days in the combined therapy.
Laryngeal papillomatosis:
/ m (if possible - perifocal area in the throat) administration at a dose of 100-150 Alfarekina thousand IU / kg of body weight daily for 20-25 days. It is recommended to repeat this treatment at intervals of 1-1.5 months for 6 months, then at intervals of 2-3 months for the next 6 months.
Multiple sclerosis:
/ m at 1 million IU 2-3 times daily for 10-15 days later - at 1 million IU a day a week for 6 months.
Malignant neoplasms
Melanoma of the skin - to 3 million IU / m 1 time per day - 10 days with an interval of 1.5 months repeat this course for 6 months;
or: by 3 million IU Alfarekina 4 times every 48 hours - followed by endolimfalno lymphotropic drug administration and 1 million IU for 4 days every month.
Uveal melanoma: 1 million IU parabulbarno daily for 10 days, 20 days refresher course for 10 days, 2 times the dose on the overall course of treatment is 30 million IU. Can not exclude the need for repeated courses in 45 days treatment Alfarekinom combined with photodestruction of the tumor and beta-applique.
Kidney cancer: by 3 million IU / m, daily for 10 days on a common course - 30 million IU, refresher courses held at intervals of 3-5 weeks for 6 months, then at intervals of 1.5-2 months in within 1 year.
Bladder cancer: in the form of intravesical instillation, 5-10 million IU per instillation, 3-6. Total course dose - 30 million IU. Repeat the treatment every 2-3 months for 1 year or 2 years.
Ovarian cancer: 5 million IU administered intraperitoneally during surgery and in the next 5 days - in drainage, then - at 3 million IU / m for 10 days between courses of chemotherapy, the total course dose Alfarekina 90 million IU. Subsequent courses may be administered at intervals of 2-3 months during the 1-1.5 years: by 3 million IU / m day - 10 days.
Breast Cancer: by 3 million IU per injection / m, daily for 10 days. Repeated courses are conducted at intervals of 1.5-2 months for 1 year and then every 2-3 months (depending on the clinical condition of the patient), appropriate alternate therapy Alfarekinom with courses of chemotherapy (or radiotherapy).
Kaposi's sarcoma: by 3 million IU per injection / m, daily for 10 days treatment is combined with monohimioterapiey prospidinum; refresher courses - 1 time per month for 6 months.
Myeloma: by 3 million IU per injection / m, daily for 10 days, a second course - a once in 1.5-3 months (4-6 courses per year).
Hemoblastosis
Chronic myeloid leukemia: 5 million IU / m daily.
Used both as mono-and chemotherapy in the complex. The duration of treatment - 6 months. Upon reaching the phase of remission maintenance therapy Alfarekinom a dose of 5 million IU daily is held for 10-12 months.
Hairy cell leukemia: at 3 million IU 3 times per week / m (a day) for 4-6 weeks. Upon reaching the phase of remission, maintenance therapy is carried out: by 3 million IU every other day - up to 12 months.
Non-Hodgkin's lymphoma: by 3 million IU three times a week / m over 12-18 months as maintenance therapy when the phase of remission achieved by chemotherapy.

CONTRAINDICATIONS: Hypersensitivity to interferon alfa-2b or to other components of the drug during pregnancy (threatened abortion).

SIDE EFFECTS: injecting Alfarekina in most cases accompanied by flu-like syndrome: fever, chills, headache and muscle pain, joint pain, general weakness. These side effects are dose-related, and usually occur only in the first days of treatment, then decrease and disappear. For relief or significant reduction of symptoms used paracetamol at a dose of 0.5-1 g for 30-40 min before the injection.
Sometimes when long courses of treatment indicated leukopenia, thrombocytopenia, passing at lower doses.

Storage: at 2-8 ° C.
Cooked pp injection drug use immediately, pp intranasal can be stored for 1 day at 2-8 ° C (refrigerator).

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