Aspirin Cardio tablets 100mg №20

Aspirin Cardio tablets 100mg №20
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Aspirin Cardio tablets 100mg №20

Description: Aspirin Cardio tablets 100mg

      CARDIO ASPIRIN (ASPIRIN CARDIO ®) ACIDUM ACETYLSALICYLICUM * B01A C06 Bayer Structure and Composition: Table. n / a gastro-solutions. 100 mg, № 20 acetylsalicylic acid 100 mg Other ingredients: cellulose, corn starch, methacrylic acid copolymer, sodium lauryl, sodium dodecyl sulfate, polysorbate 80, talc, triethyl citrate, метилгидроксипропилцеллюлоза. Table. n / a gastro-solutions. 300 mg, № 20 acetylsalicylic acid 300 mg Other ingredients: cellulose, corn starch, methacrylic acid copolymer, sodium lauryl, sodium dodecyl sulfate, polysorbate 80, talc, triethyl citrate, метилгидроксипропилцеллюлоза. : NSAID use of salicylate as an inhibitor of platelet aggregation. Acetylsalicylic acid - an active substance of the drug - long-term use at low doses exerts antiplatelet effects. The main mechanism of action of acetylsalicylic acid - non-selective inactivation of the enzyme COX, which violated the synthesis of prostaglandins, prostacyclin by endothelial cells (at doses of 300 mg) and thromboxane A2 in platelets, resulting in antiplatelet effect of the drug Aspirin Cardio, preventing the development of thromboembolism. Acetylsalicylic acid also affects the coagulation of blood, increasing fibrinolytic activity and reduced blood levels of vitamin K-dependent coagulation factors (II, VII, IX, X). Like other drugs of acetylsalicylic acid, Aspirin Cardio has anti-inflammatory, antipyretic, analgesic effect. After oral acetylsalicylic acid is metabolized to form the main active metabolite - salicylic acid. Absorption of acetylsalicylic and salicylic acids from the gastrointestinal tract occurs rapidly and completely after oral administration depends on the dosage form of the drug. Due to acid enteric shell Aspirin Cardio, an active substance is released not in the stomach, and in an alkaline environment of the small intestine. Therefore, the absorption of acetylsalicylic acid in the enteric shell occurs at 3-6 h later compared with the reception of the usual form of acetylsalicylic acid. The degree of binding to plasma proteins depends on the concentration and the average for acetylsalicylic acid, 49-70% for salicylic - 66-98%. Acetylsalicylic acid is metabolized by 50% during the first passage through the liver. Metabolites of acetylsalicylic and salicylic acids are glitsinkonyugat salicylic acid gentizinovaya acid and its glitsinkonyugat. Released in the form of metabolites mainly by the kidneys. The half-life of acetylsalicylic acid - 20 min (rate of secretion depends on the dose, the increase - rising). Penetrates through the BBB into breast milk and is determined in the synovial fluid. Indications: Treatment and prevention of unstable angina, myocardial infarction, prophylaxis of thrombosis and embolism after operations on vessels (coronary artery bypass, transdermal coronary angioplasty), prevention of transient ischemic stroke and in clinical precursors, prevention of thrombosis of coronary arteries in patients at risk, long-term prevention of migraine. APPLICATION: unstable angina, prevention of thrombosis and embolism after operations on the vessels, for the prevention of transient ischemic stroke and in clinical precursors of the recommended dose of acetylsalicylic acid is 100-300 mg / day. For a better tolerability preferred dose of 100 mg / day. The optimum period for initiation of therapy with aspirin after coronary artery bypass surgery Cardio - 24 hours after surgery. In acute myocardial infarction recommended dose of acetylsalicylic acid is 100-200 mg / day or 300 mg every other day. Aspirin Cardio is designed for prolonged use, duration of therapy determined individually. Tablets Aspirin Cardio, enteric-coated shell, should be taken before eating, drinking plenty of fluids. CONTRAINDICATIONS: hemorrhagic diathesis, specify a history of stomach problems, urogenital bleeding gipoprotrombonemiya, angioedema a history of severe liver disease, asthma. SIDE EFFECTS: The most common - nausea, anorexia, epigastric pain, mikrogemorragii in the digestive tract, sometimes with prolonged use of high doses of the drug - erosive and ulcerative lesions of the digestive tract, gastric bleeding, accompanied by chalking. When individual sensitivity to salicylates - Allergic reactions such as skin rash, hives, asthma patients - increasing the frequency of attacks of bronchospasm, in rare cases - liver dysfunction, severe skin reactions up to the development multimorfnoy erythema, renal dysfunction, hypoglycemia. SPECIAL INSTRUCTIONS: Special warnings and precautions. In patients with allergic diseases (asthma, hay fever, allergic rhinitis, hives, itching, swelling of the nasal mucosa), as well as in the case of their combination with chronic respiratory tract infections in patients with hypersensitivity to NSAIDs during treatment with aspirin may Cardio occurrence of attacks of bronchospasm. During therapy, special attention should be given to patients with peptic ulcer of the stomach and duodenum in history, with constant complaints of pain in the stomach, with hepatic dysfunction or renal disease, congestive heart failure. During long-term use of aspirin in high doses Cardio requires regular haematological monitoring (hemoglobin level and the main indicators of blood coagulation). Acetylsalicylic acid, even in low doses reduces the excretion of uric acid from the body, which may cause the appearance of an acute attack of gout in patients predisposed to urine acid diathesis. Prolonged use of analgesics, especially in combination therapy with various drugs, leads to impaired renal function, even before the development of nephropathy. About Aspirin Cardio before surgery (or dental), the intervention should notify your doctor. During pregnancy and breast-feeding should be avoided acetylsalicylic acid I and II trimester of pregnancy in case of need application is possible only under medical supervision. During the period of breast-feeding in the application of the drug in moderate doses to interrupt breast-feeding is not necessary. While taking the drug at high doses (300 mg / day) should stop breastfeeding because salicylates and products of their metabolism in small amounts get into breast milk. INTERACTION: while the application of Aspirin Cardio strengthens the action of anticoagulants (heparin, coumarin derivatives), increasing the risk of bleeding, potentiates the action and side effects of other NSAIDs and antirheumatic. In a joint application with corticosteroids increases the risk of gastrointestinal bleeding during treatment with aspirin exacerbated Cardiac side effects of methotrexate. While the application of oral antidiabetics of sulfonylureas increases their hypoglycemic effect. Aspirin Cardio reduces the effect of spironolactone, furosemide, antihypertensives and protivopodagricheskih drugs that enhance the excretion of uric acid. The use of antacids during treatment with aspirin cardio (especially in doses exceeding 3 g for adults) may reduce the high stable level of salicylate in the blood. OVERDOSE: intoxication mild sensations of vertigo, tinnitus, nausea, vomiting, epigastric pain. Overdose is most likely in the elderly and children. Treatment: gastric lavage is shown, if after taking the drug in excessive doses little time has passed, and in the future - symptomatic treatment aimed at correcting the CDF and electrolyte balance. STORAGE: at or above 25 ° C.

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